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Janumet Xr 50/500 Mg Tab 56s 10-04-2025 mood swingsSitagliptin and metformin work together to control your blood sugar. They increase the levels of insulin after a meal. They also lower the amount of sugar made by your body. Along with diet and exercise, this helps lower your blood sugar. Directions to use : as directed by the physician Side effects : tuffy or runny nose and sore throat, gas, upset stomach, indigestion, headache, upper respiratory tract infection, weakness, diarrhea, low blood sugar